MRSP infection in a person

Is MRSP zoonotic?” That’s a question I get all the time. MRSP (methicillin-resistant Staphylococcus pseudintermedius) is a canine staph (a bacterium) to which people are exposed all the time. Yes, it can infect people, but only very rarely, particularly when you consider how often they’re exposed. Nonetheless, human MRSP infections can occur.

My typical answer to the question is “Yes, but…” followed by an explanation of the overall low risk. My general line is:

  • It can be transmitted to people.
  • Human infections are very rare
  • There’s no use panicking over MRSP or being draconian when you have an infected animal.
  • At the same time, no one wants a highly resistant infection, so some basic measures should be used to reduce the risk of transmission.

Issues are also greater when people with compromised immune systems are involved, and a recent paper highlights this.

The paper (Savini et al, Journal of Clinical Microbiology 2013) describes MRSP infection in a 65-year-old man who was immunocompromised because of a bone marrow transplant. He developed a wound infection, and his physicians and the diagnostic lab did a pretty comprehensive study of the bacterium they isolated from the wound, ultimately determining it to be MRSP.

The man lived “close to a pet dog and farm cows," whatever that means. The dog was probably the source, but unfortunately (as is common) no efforts were made to see if the dog was carrying MRSP, to see if the cows were positive for MRSP (since this bug can rarely be found in cattle), or to type the isolate to see how it compares to strains that are typically found in animals.

Will this report change my answer to the first question? No. It gives me another example of a human MRSP infection, but such events are still exceedingly rare and this individual was highly immunocompromised, having graft-vs-host disease after his bone marrow transplant.

We don’t need to be afraid of MRSP, but we need to realize there is some risk, and the risk is presumably higher for certain people (e.g. very young, very old, people with compromised immune systems). We therefore need to use some basic infection control and hygiene practices to reduce the incidence of transmission of MRSP and other potentially harmful microorganisms from animals to people.

More information about MRSP can be found on the Worms & Germs Resources - Pets page.

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