Transmission of herpesvirus from a person to a rabbit
A paper in the July 1 edition of the Journal of the American Veterinary Medical Association (Muller et al) describes a case of encephalitis (brain inflammation) in a rabbit caused by human herpesvirus type 1. The owner had a severe herpes infection with genital and oral lesions five days before the rabbit got sick, and reported "intensive" nose-to-nose and mouth-to-nose contact with the rabbit. The rabbit started off with a decreased appetite and excessive tear production (epiphora) in one eye. Then other signs of eye and neurological disease developed. Despite aggressive treatment, the rabbit deteriorated and was euthanized after a week of hospitalization. Subsequent testing identified human herpesvirus type 1 in the rabbit's brain.
Human herpesvirus type 1, also called herpes simplex viruses type 1 (HSV-1), is a common sexually transmitted disease (STD) in people. It can cause oral, genital and ocular (eye) lesions. Humans are the primary host of this virus, but it has been found in species such as rabbits, rats, mice and chinchillas. In rabbits, it usually causes encephalitis, and is almost always fatal for these animals.
This case shows how viruses typically associated with one species can sometimes affect others. While we usually focus on microorganisms moving from animals to humans, they can also move in the opposite direction, as was presumably the case here. Close face-to-face contact with the infected owner was probably the source of the virus. This is an example of an uncommon event, but one that should not be ignored.
If you have an active herpesvirus infection:
- Limit close contact with rabbits (and, to be on the safe side, probably restrict contact with other pets as well). In particular, avoid contact with the mouth, nose or eyes.
- Wash your hands or use an alcohol hand sanitizer regularly, particularly after using the washroom or having any contact with infected sites/sores.
- Make sure herpesvirus infection is considered if your rabbit develops eye or neurological disease.
The risk of rabbits transmitting human herpesvirus is completely unclear. Common sense dictates that anyone hanlding a potentially infected rabbit should restrict contact with the eyes/mouth/nose, wear gloves, wash hands after contact (even if gloves were worn) and avoid contamination of clothing.
Plague in a rabbit: New Mexico
Plague has been diagnosed in a dead rabbit found on a private residence in New Mexico. Plague, also known as the black death, is a highly fatal disease of humans and many animals caused by the bacterium Yersina pestis. While often considered a disease of mainly historical interest - having killed a large percentage of people on the planet during a few pandemics over the centuries - plague is actually still alive and well in some regions. In North America, most cases occur in New Mexico, Arizona, Colorado and California.
Yersinia pestis primarily lives in wild rodents and is transmitted by fleas. Many different animal species, including cats, dogs, rabbits and people, can be infected if bitten by a flea from an infected rodent (hence the historical association of the disease with rats). Predatory species (like dogs and cats) can also become infected by eating infected animals. Dogs are relatively resistant to plague and usually only develop mild disease, while cats and rabbits are as susceptible as people, and can develop bubonic, septicemic or pneumonic plague. Transmission of plague from pets to people can occur, and most often involves cats. People can become infected by close contact with sick pets, or being bitten by a flea from such a pet.
Preventing plague in animals involves flea control and reducing exposure to infected wildlife. In areas where plague is active, all pets should be on a flea control program. Cats should be kept indoors to reduce the risk of exposure (e.g. keeps them from hunting infected rodents). Dogs and cats should not be allowed to have contact with dead animals of any kind. Measures to reduce rodent infestations in and around the house are also important.
More information on plague is available in the Worms & Germs archives.
Ban the Easter bunny?
As Easter approaches, so do the annual commentaries about concerns with people buying "Easter bunnies" (the real variety, not the chocolate version) without knowing what they are getting into. It's a big problem because a lot of spontaneous Easter bunny purchases end up abandoned at humane societies (or worse) after a few months.
In general, rabbits can be great pets. However, they have special management needs, and they can live for a relatively long time (years), so people need to think about whether a rabbit is the right pet for them, and whether they can (or will) look after it properly for the duration of its life.
Rabbits are pretty low risk in terms of zoonotic disease transmission. There are a few concerns but these are typically quite manageable with pretty basic hygiene measures. Knowing how to properly handle a rabbit is very important to prevent scratches (and bites) to the handler, and potentially serious injuries to the rabbit. For more information and a video about safe rabbit handling, see the previous Worms & Germs post entitled "Safe Rabbit Handling - For You And Your Rabbit".
Easter may be as good a time as any to get a rabbit - if it's not a spontaneous decision and you've really put some serious thought into it. Part of that process needs to include finding out about ways to reduce the risk of illness and injury associated with rabbits. This type of information can be found in the rabbit information sheets on the Worms & Germs Resources page.
Cheyletiella - The walking dandruff
Cheyletiella is a genus of mites that commonly affect dogs (C. yasguri), cats (C. blakei), rabbits (C. parasitovorax), and occasionally people. Unlike Sarcoptes species (the mites that cause sarcoptic mange), these mites live on the surface of the skin and do not burrow into deeper layers. They feed on dead skin cells and occasionally tissue fluid. Infestation with these mites can be very itchy, but not always. Cats in particular can carry the mites without any visible abnormalities of their skin or fur. Typically, however, the affected animal's fur becomes crusty, scaly and inflamed, and sometimes patches of fur may be lost. The mites are usually a little less than a half-millimetre long (so they are visible to the naked eye if you look closely) and grayish-white. They tend to be quite active and crawl around (but they don't jump like fleas), which gives them the appearance of walking dandruff. Diagnosis is easy if the mites are seen strolling around on a table or blanket, otherwise they may be found on a "scotch tape test" or superficial skin scraping.
People can be affected too if they have close contact with a pet carrying Cheyletiella. Lesions, which usually take the form of single or grouped small red bumps on the skin, typically appear on the arms, trunk or thighs, and sometimes can be extremely itchy! It is rare to see the mites themselves on a person - usually they're found on the pet. The good news is these mites can't actually complete their life cycle or survive for long on people, and in the environment even the hardiest forms of the parasite (usually the eggs and adult females) die within about ten days. So once the source of the mites is eliminated (by treating the pet with an appropriate anti-parasitic drug which your vet can prescribe), the signs in any affected people will resolve on their own without specific treatment (but you might want something for the itch!).
Photo: Light micrograph of C. yasguri from a dog (credit: Dr. M. Dryden, College of Veterinary Medicine, Kansas State University)
Neurological bunnies: Encephalitozoon cuniculi
Encephalitozoon spp. are single-celled microsporidian parasites that can cause infection in the intestinal tract of animals and people, and sometimes infection in other parts of the body (systemic infection). Cases of infection with these parasites (encephalitozoonosis) have been reported in countries all over the world. The species E. bieneusi and E. intestinalis are the most common. A much less common species, E. cuniculi, is thought to be one of the most virulent microsporidia that infects humans (i.e. it causes the most severe infections). Encephalitozoonosis is rare in healthy people, but it is a common complication in patients with weakened immune systems. Encephalitozoon cuniculi can also be found in many animal species, particularly in rabbits. Most infections in rabbits do not cause illness (i.e. subclinical infections), but when disease occurs it typically causes neurological signs. In these cases the parasite tends to attack the brain and kidneys. The primary means of transmission between rabbits is E. cuniculi spores shed in the urine. Organ damage in the few human cases that have been reported have also been primarily in the brain and kidneys.
Direct transmission of this parasite from rabbits to humans has not been reported, but because there is also no evidence that it can't be transmitted from rabbits, the disease is so severe when it does occur, and the parasite is so common in rabbits, it is still prudent to take a few simple precautions. This includes washing your hands after handling rabbits, and keeping rabbits away from food preparation areas and food meant for human consumption. Anyone with a weakened immune system should be particularly careful, and ideally should have someone else clean out their rabbit's enclosure on a regular basis.
In general, the risk of illness in a rabbit and zoonotic transmission can be reduced by proper handling, good management, personal hygiene and routine healthcare. A rabbit that is not stressed and is well cared for is less likely to be susceptible to infection, and therefore less likely to transmit infection to a person. More information about rabbits is available on the Worms & Germs Resources page.
Safe rabbit handling - for you and your rabbit!
Knowing how to properly handle a rabbit is very important for rabbit owners. If done incorrectly, the handler, the rabbit, or both could be injured. A rabbit's powerful hind legs and flighty nature (being a prey species) are a dangerous combination. Even though rabbits may not do so intentionally, the nails on their hind feet can inflict serious scratches (rivaling those of any cat or dog) if they are trying to get away. Rabbits can break their backs simply by struggling against improper restraint because of the amount of force they can generate with their hind legs.
Knowing the basics about how to handle rabbits safely and correctly can greatly reduce risks to both the handler and the animal. Click on the image below to see a video by Dr. Erin Harrison of the Ontario Veterinary College Avian & Exotics Service about some tips on approaching and handling rabbits safely.
Tularemia Trouble
A case of pneumonic tularemia was recently reported in New York City.
Tularemia is a disease caused by the bacterium Francisella tularensis. It causes different signs of illness depending on how the bacteria enter the body. If the bacteria are inhaled, it tends to cause pneumonia (pneumonic tularemia). If the bacteria get in through a break in the skin, infection may cause the local lymph nodes (glands) to become very swollen, and in some cases the skin itself may become infected resulting in the formation of large sores (ulcers). Infection can also cause sores in the mouth and diarrhea. The earliest, most common signs are things like fever, headache, chills, sore muscles, and sore throat which often come on very abruptly. The infection can be treated with antibiotics, but it is important to see a doctor and start treatment as soon as possible.
Tularemia is also sometimes called "rabbit fever," because the bacteria are often carried by animals such as rabbits and hares. Rodents (including beavers, rats, mice, squirrels etc.) can also carry F. tularensis, and occasionally so can cats and dogs. Some biting insects like deerflies and certain species of ticks can carry the bacteria and transmit it when they bite. Francisella tularensis can also survive in water and soil for a long time. People can become infected by being bitten by an infected insect, handling an infected animal (dead or alive), or coming into contact with feces from an infected animal. Occasionally a person may inhale the bacteria if it is in the air, as may happen with disturbed, dusty, contaminated soil.
More information on tularemia can be found on the CDC's tularemia website.
Things you can do to avoid tularemia:
Avoid touching or handling wildlife (dead or alive), especially rabbits and rodents.
Don't let your pet touch or eat dead animals.
Always wash your hands if you have been working outside in the dirt/soil.
Wear insect repellent containing DEET (visit the Health Canada website for more safety tips)
Make sure you only wash food with and drink water that has been properly treated.
One of the reasons tularemia is such a big deal is it is very infectious - as few a ten bacteria can be enough to make even a healthy person sick! But it is still quite uncommon in North America - about 100-200 cases are reported in people in the USA every year. Between 2002-2004 there were 34 cases reported in Canada, most of which occurred in Quebec and in adults. However, infection can be fatal in a very small number of cases, especially if proper treatment is not given as soon as possible.
Information Sheets for Pet Owners
INFORMATION SHEETS specifically for KIDS, for VETERINARIANS, for PHYSICIANS and for PUBLIC HEALTH PERSONNEL are also available on the Worms & Germs RESOURCES page!
Click on the highlighted topics below for information sheets. Topics that are not highlighted are in development and coming soon. Sheets for other animal species and diseases are also under development and will be added when they are available.
| Animals | Diseases | Other |
| Dogs | Rabies | Litter Boxes |
| Cats | Giardia | Sandboxes |
| Turtles | Toxoplasma | Cat Bites |
| Hamsters | Leptospira | Raw Meat |
| Rabbits | Clostridium difficile | Petting Zoos |
| Pet Birds | Cryptosporidium | Needlestick Injuries |
| Reptiles | MRSA | |
| MRSP | ||
| Salmonella | ||
| Ringworm | ||
| Campylobacter | ||
| Bartonella henselae | ||
Please Remember:
- Your veterinarian and physician are your ultimate resource for information about the health of your pets or your family.
- Information provided here is accurate to the best of our knowledge, but infectious diseases can be unpredictable and these sheets are for general information purposes only.
- There can be great variation in disease risks in different geographic areas. The information provided was developed for Ontario, Canada, but most of the information is relevant for other regions as well.
