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Lisa Ciesinski, Sebastian Guenther, Robert Pieper, Martin Kalisch, Carmen Bednorz, Lothar H. Wieler
High dietary zinc feeding promotes persistence of multi-resistant E. coli in the swine gut
www.plosone.org
www.plosone.org
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1.508 0 Td
(bacteria)Tj
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(the)Tj
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(effect)Tj
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(of)Tj
1.0148 0 Td
(zinc)Tj
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(on)Tj
1.2756 0 Td
(multi-resistance)Tj
/F15 1 Tf
6.6387 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()15()3(\n)]TJ
/F9 1 Tf
1.8198 0 Td
(and)Tj
1.7292 0 Td
(to)Tj
1.0261 0 Td
(substantiate)Tj
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(own)Tj
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(recent)Tj
-34.6448 -1.2983 Td
(results)Tj
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(our)Tj
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(understanding)Tj
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(the)Tj
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(of)Tj
/F15 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F15 1 Tf
0.9921 0 Td
[()7(\n)10()12()]TJ
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0.9978 0 Td
[()7(\n)10()12()]TJ
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(\(iv\))Tj
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(the)Tj
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1.4684 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
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0.9921 0 Td
[()7(\n)10()12()]TJ
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1.559 0 Td
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(the)Tj
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(start)Tj
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1.4683 0 Td
(zinc)Tj
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1.8708 0 Td
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(an)Tj
1.2019 0 Td
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(high)Tj
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(zinc)Tj
1.8708 0 Td
(feeding)Tj
3.1635 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(percentage)Tj
4.5467 0 Td
(of)Tj
-34.7468 -1.2982 Td
(multi-resistant)Tj
/F15 1 Tf
6.0887 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F15 1 Tf
0.9978 0 Td
[()7(\n)10()12()]TJ
/F9 1 Tf
1.5591 0 Td
(isolates)Tj
3.1181 0 Td
(and)Tj
1.7291 0 Td
(therefore)Tj
3.8551 0 Td
(substantiate)Tj
4.9776 0 Td
(recent)Tj
2.7099 0 Td
(findings.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 525.2031 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F16 1 Tf
-6.4961 -1.5023 Td
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3.9827 0 Td
(housing,)Tj
3.7937 0 Td
(and)Tj
1.7906 0 Td
(diets)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 490.2236 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Offspring)Tj
4.0705 0 Td
(of)Tj
1.0148 0 Td
(animals)Tj
3.3335 0 Td
(and)Tj
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(experimental)Tj
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(conditions)Tj
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(have)Tj
2.0579 0 Td
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(in)Tj
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(previous)Tj
3.651 0 Td
(studies)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-35.9884 -1.3039 Td
(21)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(30)Tj
0 g
(].)Tj
1.7348 0 Td
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3.0784 0 Td
(a)Tj
0.6519 0 Td
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2.007 0 Td
(of)Tj
1.0148 0 Td
(32)Tj
1.1678 0 Td
(landrace)Tj
3.634 0 Td
(piglets)Tj
2.795 0 Td
(were)Tj
2.1259 0 Td
(weaned)Tj
3.2599 0 Td
(25)Tj
/F17 1 Tf
[()]TJ
/F9 1 Tf
(1)Tj
2.2166 0 Td
(days)Tj
1.9956 0 Td
(after)Tj
2.0353 0 Td
(birth)Tj
2.194 0 Td
(and)Tj
1.7291 0 Td
(randomly)Tj
-33.0347 -1.2982 Td
(allocated)Tj
3.7587 0 Td
(to)Tj
1.0261 0 Td
(two)Tj
1.7064 0 Td
(different)Tj
3.6567 0 Td
(feeding)Tj
3.1635 0 Td
(groups)Tj
2.9707 0 Td
(balancing)Tj
4.0932 0 Td
(for)Tj
1.3889 0 Td
(gender,)Tj
3.2032 0 Td
(litter,)Tj
2.3527 0 Td
(and)Tj
1.7291 0 Td
(body)Tj
2.2167 0 Td
(weight.)Tj
3.1124 0 Td
(Ani-)Tj
-34.3783 -1.2983 Td
(mals)Tj
2.0806 0 Td
(were)Tj
2.1203 0 Td
(housed)Tj
3.0954 0 Td
(in)Tj
1.0375 0 Td
(flatdeck)Tj
3.3562 0 Td
(pens)Tj
2.0692 0 Td
(with)Tj
1.9956 0 Td
(ad)Tj
1.1849 0 Td
(libitum)Tj
3.1521 0 Td
(access)Tj
2.6475 0 Td
(to)Tj
1.0262 0 Td
(feed)Tj
1.8822 0 Td
(and)Tj
1.7291 0 Td
(water.)Tj
2.6589 0 Td
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2.3017 0 Td
(were)Tj
2.126 0 Td
(based)Tj
-34.4634 -1.3039 Td
(on)Tj
1.2755 0 Td
(wheat,)Tj
2.812 0 Td
(barley,)Tj
2.88 0 Td
(corn,)Tj
2.296 0 Td
(and)Tj
1.7291 0 Td
(soybean)Tj
3.4583 0 Td
(meal)Tj
2.143 0 Td
(and)Tj
1.7291 0 Td
(were)Tj
2.126 0 Td
(described)Tj
4.0478 0 Td
(previously)Tj
4.354 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
2.0749 0 Td
(Corn)Tj
2.3131 0 Td
(starch)Tj
2.6362 0 Td
(was)Tj
-35.875 -1.2983 Td
(partially)Tj
3.4865 0 Td
(replaced)Tj
3.5887 0 Td
(by)Tj
1.1792 0 Td
(analytical)Tj
4.0081 0 Td
(grade)Tj
2.4435 0 Td
(zinc)Tj
1.8709 0 Td
(oxide)Tj
2.4094 0 Td
(\(Sigma)Tj
3.0217 0 Td
(Aldrich,)Tj
3.4923 0 Td
(Taufkirchen,)Tj
5.3687 0 Td
(Germany\),)Tj
-30.869 -1.2982 Td
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2.6475 0 Td
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1.7008 0 Td
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4.8529 0 Td
(by)Tj
1.1792 0 Td
(atomic)Tj
2.9706 0 Td
(absorption)Tj
4.5355 0 Td
(spectrometry)Tj
5.4935 0 Td
(\(AAS)Tj
2.4037 0 Td
(vario)Tj
2.2507 0 Td
(6)Tj
0.6973 0 Td
(spectrometer;)Tj
5.6806 0 Td
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-34.4123 -1.304 Td
(tik)Tj
1.2812 0 Td
(Jena,)Tj
2.1827 0 Td
(Jena,)Tj
2.177 0 Td
(Germany\))Tj
4.3313 0 Td
(resulting)Tj
3.7247 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(final)Tj
2.0069 0 Td
(concentration)Tj
5.8167 0 Td
(of)Tj
1.0148 0 Td
(72)Tj
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(mg)Tj
1.5024 0 Td
(zinc/kg)Tj
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(diet)Tj
1.7405 0 Td
(\(control\))Tj
3.7984 0 Td
(and)Tj
-35.6029 -1.2982 Td
(2103)Tj
2.1203 0 Td
(mg/kg)Tj
2.7949 0 Td
(\(zinc)Tj
2.2167 0 Td
(group\))Tj
2.948 0 Td
(respectively.)Tj
5.108 0 Td
(All)Tj
1.3946 0 Td
(feed)Tj
1.8879 0 Td
(was)Tj
1.6951 0 Td
(produced)Tj
4.0478 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(experimental)Tj
5.4595 0 Td
(site)Tj
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(under)Tj
-33.664 -1.2983 Td
(controlled)Tj
4.3199 0 Td
(conditions.)Tj
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1.2643 0 Td
(pure)Tj
2.0579 0 Td
(corn)Tj
2.075 0 Td
(starch)Tj
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(with)Tj
1.9955 0 Td
(low)Tj
1.6555 0 Td
(inclusion/replacement)Tj
9.1785 0 Td
(level)Tj
2.0126 0 Td
(was)Tj
1.7008 0 Td
(replaced)Tj
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(by)Tj
1.1792 0 Td
(zinc)Tj
1.8708 0 Td
(oxide)Tj
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1.3833 0 Td
(zinc)Tj
1.8709 0 Td
(content)Tj
3.2711 0 Td
(adjustment)Tj
4.7168 0 Td
(we)Tj
1.3267 0 Td
(suspect)Tj
3.1294 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
(differences)Tj
4.5694 0 Td
(in)Tj
1.0318 0 Td
(biological)Tj
4.0932 0 Td
(zinc)Tj
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(in)Tj
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(the)Tj
1.4683 0 Td
(corn)Tj
2.0693 0 Td
(are)Tj
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(so)Tj
1.0885 0 Td
(low)Tj
1.6554 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(neglectable.)Tj
4.8812 0 Td
(No)Tj
1.4627 0 Td
(antimicrobial)Tj
5.6126 0 Td
(substances)Tj
4.4673 0 Td
(were)Tj
2.1203 0 Td
(administered)Tj
5.4879 0 Td
(to)Tj
1.0261 0 Td
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(piglets)Tj
2.7949 0 Td
(or)Tj
1.0998 0 Td
(their)Tj
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(mothers.)Tj
3.753 0 Td
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1.7859 0 Td
(experimental)Tj
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1.8368 0 Td
(followed)Tj
3.651 0 Td
(the)Tj
1.4684 0 Td
(institutional)Tj
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(and)Tj
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(national)Tj
3.5036 0 Td
(guide-)Tj
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(lines)Tj
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1.3889 0 Td
(the)Tj
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(care)Tj
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(and)Tj
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(animals)Tj
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1.7291 0 Td
(was)Tj
1.7008 0 Td
(approved)Tj
3.9741 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(local)Tj
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(state)Tj
2.0352 0 Td
(office)Tj
2.4151 0 Td
(of)Tj
1.0148 0 Td
(occupational)Tj
-31.9972 -1.3039 Td
(health)Tj
2.6758 0 Td
(and)Tj
1.7292 0 Td
(technical)Tj
3.8154 0 Td
(safety)Tj
2.4774 0 Td
(`Landesamt)Tj
4.8302 0 Td
(fu)Tj
0 Tc
0.3629 0 Td
()Tj
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(r)Tj
0.5896 0 Td
(Gesundheit)Tj
4.8416 0 Td
(und)Tj
1.8255 0 Td
(Soziales,)Tj
3.5716 0 Td
(Berlin')Tj
2.8743 0 Td
(\(LaGeSo)Tj
3.651 0 Td
(Reg.)Tj
1.9559 0 Td
(Nr.)Tj
-35.6539 -1.2983 Td
(0296/13\).)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 269.0078 cm
BT
/F16 1 Tf
1 TL
-0.0033 Tc
0 0 Td
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ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
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1.9842 0 Td
(study)Tj
2.3924 0 Td
(investigated)Tj
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(occurrence)Tj
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[()]TJ
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0.9921 0 Td
[()7(\n)10()12()]TJ
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1.7348 0 Td
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2.4548 0 Td
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2.2904 0 Td
[()]TJ
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(.)Tj
/F15 1 Tf
0.9921 0 Td
[()7(\n)10()12()]TJ
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1.5591 0 Td
(habitat)Tj
2.9877 0 Td
(at)Tj
0.9524 0 Td
(three)Tj
2.2677 0 Td
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-33.8624 -1.3039 Td
(time)Tj
2.0295 0 Td
(points)Tj
2.7156 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
1.2643 0 Td
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1.2019 0 Td
(the)Tj
1.4683 0 Td
(age)Tj
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(24)Tj
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1.9956 0 Td
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2.0409 0 Td
(day)Tj
1.6327 0 Td
(before)Tj
2.744 0 Td
(weaning\))Tj
3.9288 0 Td
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2.1373 0 Td
(were)Tj
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(collected)Tj
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(of)Tj
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(all)Tj
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(32)Tj
1.1678 0 Td
(piglets)Tj
2.8006 0 Td
(to)Tj
1.0262 0 Td
(investigate)Tj
4.4617 0 Td
(the)Tj
1.4683 0 Td
(status)Tj
2.5001 0 Td
(quo)Tj
1.7632 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(feces)Tj
/F15 1 Tf
2.1373 0 Td
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