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TL;DR: There’s no proven premedication strategy that reliably prevents adverse reactions to vaccines; instead focus on patient risk assessment, appropriate vaccine selection, close monitoring, and prompt treatment if an adverse event occurs.  

Vaccine adverse events (AEs) in pets are uncommon, but that doesn’t mean their inconsequential. Clients (and veterinarians) worry about them a…

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Picture this: An owner takes their dog to a veterinarian for routine vaccines. The veterinarian recommends a DAPP vaccine (distemper, adenovirus, parvovirus, parainfluenza), as well as vaccination for rabies and leptospirosis. After some discussion, the owner declines the lepto vaccine, but proceeds with the others. The next day, they call back after doing some reading…

Let’s face it, approaches to vaccination in companion animals are based partly on direct evidence, partly on extrapolation from other species, partly on expert opinion, and partly on “this is what we do because it’s what we’ve always done.” The evidence base for much of what we do is incomplete, and for a…